Background
The Affymetrix platform is a data intensive platform. In order to effectively manage, analyze, and integrate GeneChip® array related information, special accommodations have been implemented within our supporting software. Our software takes advantage of database technology in order to accomplish its goal of delivering descriptive array information and annotation for the thousands of expression events measured by your Affymetrix GeneChip arrays. Database technology is also used in order to facilitate analysis across multiple experiments.

The use of Library Files by MAS, the publishing of array data into AADM-compliant databases by MicroDB, and the saving of private annotations during analysis by DMT are examples of database mediated features which are delivered by the Affymetrix platform.

Unauthorized Access and Computer Virus Assaults
We have become aware of unauthorized workstation access and virus assaults which were occurring at some accounts. These attacks exploit a weakness in our software's use of Microsoft Data Engine (MSDE) databases on the desktop. MSDE use requires a system password, and Affymetrix software was built to utilize MSDE under its default configuration - a system administrator (SA) password that is "null".

While common, a null SA password can be exploited by malicious individuals in order to gain control of your desktop computer. When Affymetrix became aware that these attacks were occurring, it immediately created a utility to thwart this belligerent activity. This utility is called "MSDE Lock."

Many of our customers will not experience this malicious activity because they have invested in network firewalls and desktop virus scanners which together prevent the attacks. However, others utilize more open networks which operate at lower direct cost and promote broader interchange with the global Internet. These open networks are often also more vulnerable, and allow external hacking and virus propagation to occur. It is for these latter environments that use of the MSDE Lock Utility is strongly recommended.

1. Create a new directory and unzip the files into that directory.
   
2. Read the MSDE Lock.pdf file for installation instructions and use of the utility.