Can the GeneChip Mapping 100K Set be used to study chromosomal amplification, deletion, and loss of heterozygosity?
Yes. There have been several publications showing that the GeneChip Mapping 100K Set can be highly effective for studying allelic imbalance. The Mapping 100K Set can detect chromosomal amplification, deletion, and genotyping information in one experiment, allowing greater understanding of the molecular mechanisms underlying loss of heterozygosity events. The GeneChip® Chromosome Copy Number Tool is software freely available on the Affymetrix Tools page to enable these studies.