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Exon Array Analysis

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What is DABG, PLIER?

DABG stands for "detection above background" and is a detection metric generated by comparing Perfect Match probes to a distribution of background probes. This comparison yields a p-value which is then combined into a probe set level p-value using the Fischer equation. PLIER stands for "Probe Logarithmic Intensity Error" and is a model-based signal estimator which benefits from multi-array analysis. For more information on DABG, see the "Exon Array Background Correction" white paper; for more information on PLIER, refer to the PLIER Technical Note.