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Affymetrix DevNet Update


Affymetrix Developer News

August 2007

QUICK LINKS

NetAffx Update

New Additions To The Data Resource Center


NetAffx Update

NetAffx Annotation Update 23 Available in July
Annotations updated for all Expression and Exon Arrays.  Full source data information is available here.
  • Nearest/Overlapping Gene Mappings are now available for all Mapping Arrays.
  • Rhesus Array human mappings are now fully replaced with Rhesus genes where available.
To eliminate some poor quality probe set annotations, ENSEMBL EST Gene records are discontinued.

NetAffx Annotation File Patch - KEGG Annotations Discontinued
KEGG Pathway Annotations will no longer be available through NetAffx. Archive Annotation Files have also been revised to reflect this policy.  MAGE XML files may be temporarily offline while they are amended.  A patch of the 'Total Probes' column in control Exon and Gene Annotation CSV files is also included.

NetAffx Feature Update Available in Early August
To improve your interactive GeneChip array data analysis, we are updating NetAffx features and retiring some of its features. The first set of Major updates include the following.  More feature updates will be coming through the Fall.
  • Updated Quick Queries - better sorted responses in seconds
  • Export can now save the first 10,000 probe set records
  • Streamlined navigation
  • Updated NetAffx help
    • Glossaries explain all the probe set annotations details pages
    • New Revised NetAffx FAQ
As part of the update, three features have been retired:  the Probe Set Display, the Array Finder and the GO Browser. Alternatives to these functions are suggested/available as below:
  • The Probe Set Display: Replaced by probe level tracks for Integrated Genome Browser and the UC Santa Cruz Genome Browser
  • Array Finder: Finding genes of interest on NetAffx products with a conventional NetAffx Query is now preferred over the Array Finder
  • GO Browser: Users can graphically view the relationship of GO terms with the following:
    • AMIGO
    • EBI's GO Browser
    • Genmapp's desktop application allows users to view a graphical representation of associated GO terms for input probe set IDs or Gene Symbols/Unigene IDs from a NetAffx export.
    • GenInfoViz allows users to view a graph of associated GO terms for an input Gene Symbols, or Unigene IDs from a NetAffx export.

New Additions to the Data Resource Center

Tiling/Regulation Data
Updated SP1 Data
Sample attributes added to SP1 data on the Human Promoter Tiling Array. These data are available in AGCC formats with richly annotated sample attributes stored in AGCC formatted ARR files with programmatic GUID links to the associated CEL files.

New Human Tiling 2.0 data available on GEO
DNaseI sensitivity/hypersensitivity using DNase-array method (Sabo et al Nature Methods 3:511-18, 2006) on Affymetrix whole-genome tiling DNA microarrays. Contributed to GEO by Stamatoyannopoulos J. Link to data available from GEO.

New Human Promoter 1.0R Tiling data available on GEO
ChIP-chip analysis of human DREAM complex subunits in GO-arrested and S-phase synchronized cells. Contributed to GEO by Zhu X, Lui XS, Sadasivam S, Litovchick L, DeCaprio JA. Link to data available from GEO.

Exon Data
Updated Murine Exon Data
The GCOS versions of the Murine Exon data had become corrupt and we have recently replaced and validated this data set.

Updated Human Exon tissue and Mixtures data
We have edited the AGCC versions of the Human Exon Tissue and Mixture data to include richly annotated ARR files with programmatic links to the associated CEL and CHP.

New Human Exon data from recent publications available on GEO
Identification of Genetic Variants Contributing to Cisplatin-Induced Cytotoxicity using a Genome-wide Approach (Huang, Rong Stephanie; Duan, Shiwei; Shukla, Sunita J.; Kistner, Emily; Clark, Tyson A.; Chen, Tina X.; Scweitzer, Anthony C.; Blume, John E.; Dolan, M. EileenHuang, Rong Stephanie; Duan, Shiwei; Shukla, Sunita J.; Kistner, Emily; Clark, Tyson A.; Chen, Tina X.; Scweitzer, Anthony C.; Blume, John E.; Dolan, M. Eileen) Link to data stored at GEO GSE7761

A Novel Genome-Wide Approach to Identify Genetic Variant that Contribute to Etoposide-Induced Cytotoxicity (R.S. Huang, S. Duan, W.K. Bleibel, E. O. Kistner, W. Zhang, T. A. Clark,  N. Cox and M. E. Dolan) Link to data stored at GEO GSE7792

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