Toxicogenomics is a scientific sub-discipline that combines toxicology with genomics, such as microarray technology. Whether you work at a government or academic research institute, or in the pharmaceutical and biotech industries, Affymetrix solutions can accelerate your toxicology decisions.

Affymetrix offers a complete solution for small molecule and biotherapeutics development. With GeneChip® technology, you can:

• Identify mechanism of toxicity - Find major, specific gene expression changes with biomarkers at the molecular level
• Select compounds and design backup compounds using gene expression
• Reveal species differences in toxicological studies at the molecular level
• Accelerate your toxicological interpretation of gene expression with a ToxFX™ Report
• Accelerate your throughput and productivity - Run 96 samples at once with Affymetrix' high-throughput solutions

Tox Publications

Gold Standard For Toxicogenomics Studies

• The most widely used platform in toxicogenomics research
• The highest number of publications
• Commercial toxicogenomics database support
  • Entelos® (previously Iconix)
  • Gene Logic®
• High-throughput solutions that allow you to process up to 96 samples at once
• Best annotation tools: The NetAffx® Analysis Center — Get to the biology faster and save time!

Microarray Quality Control (MAQC)

• Highest quality, as demonstrated by the Microarray Quality Control (MAQC) Study
• CV below 5 percent
• Highest correlation to TaqMan® and transcriptional coverage

Back to Top >

The Affymetrix Toxicogenomic Platform offers complete species coverage for toxicology, including rat, mouse, canine, rhesus macaque, porcine, zebrafish and human arrays.

Rat Microarrays / Array Plates

• Rat Genome 230 2.0 Array
• HT RG-230 PM Array Plate
• HT Rat Focus Array Plate
• Rat ToxFX 1.0 Array

Mouse Microarrays / Array Plates

• Mouse Genome 430 2.0 Array
• HT MG-430 PM Array Plate
• HT Mouse Genome 430 Array Plate Set

Other Organisms / Array Plates

• Canine Genome 2.0 Array
• Rhesus Macaque Genome Array
• Porcine Genome Array
• Zebrafish Genome Array

Human Microarrays / Array Plates

• Human Genome U133 Plus 2.0 Array
• HT Human Genome U133 Array Plate Set
• HT HG-U133+ PM Array Plate

Back to Top >

Microarrays as a New Tool for the Toxicologist in Drug Discovery and Development

Abbott's Eric Blomme and Bayer's Heidrun Ellinger-Ziegelbauer discuss toxicogenomics in predictive toxicology, mechanistic toxicology and target selection.

View More >

Toxicogenomics Impacts Decision-making Early in the Pipeline at Eli Lilly

Eli Lilly's Tim Ryan discusses using gene expression data to speed development decisions as molecules move through early toxicology assessment.

View More >