The Affymetrix GeneChip® Xenopus laevis Genome 2.0 Array can be used to study the whole genome of Xenopus laevis on a single array. The array is comprised of more than 32,400 probe sets representing more than 29,900 X. laevis transcripts, and was designed in close collaboration with the Xenopus research community as part of the Affymetrix® GeneChip® Consortia Program. Sequences used in the design of the array were selected from the X. laevis UniGene build 69 (July 2006) and GenBank® mRNAs (through September 12, 2006).
X. laevis is one of the most important model organisms in developmental biology. Much of the current understanding of early embryonic development derives from experiments performed in the Xenopus embryo.
The GeneChip Xenopus laevis Genome 2.0 Array is designed specifically to monitor gene expression in X. laevis, providing significant utility in developmental studies, such as induction and over-expression. The Xenopus laevis 2.0 Array complements the GeneChip® Xenopus tropicalis Genome Array, which can be used to combine genetic approaches with the established strengths of X. laevis.
The GeneChip® Xenopus laevis Genome 2.0 Array is especially useful for researchers interested in identifying the genetic mechanisms critical to the following processes:
- Primordial germ cell migration
- Oocyte maturation
- Programmed cell death
- Pluripotency and lineage specificity
- Nuclear transport
- Patterning events
- Chromosome replication
- Chromatin assembly
- Cell cycle progression
- Intracellular signaling
- Organogenesis
- Oncogenesis
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