Analysis of mitochondrial mutations is informative for a variety of applications from disease genetics to forensic identification. The GeneChip® Human Mitochondrial Resequencing Array 2.0 provides the most efficient and cost-effective method for detecting germ line and heteroplasmic mutations by delivering the complete mitochondrial genome with minimal PCR in only 48 hours.

Features and Benefits

• More Information Per Experiment
  The Human Mitochondrial Resequencing Array 2.0 interrogates the entire 16 kb genome on a single array.



• Less PCR
  The robust Mitochondrial Resequencing Assay amplifies the entire genome in only three PCR reactions.



• No Assembly Required
  The Mitochondrial Resequencing Array 2.0 delivers completed sequence in 48 hours with minimal alignment.
  

Array Specifications and Components

Format	169
Sequence Capacity	16kb
Feature Size	8 µm
Instrumentation	GeneChip® Scanner 3000
Software Support	GeneChip® Operating Software (GCOS) GeneChip® Sequence Analysis Software (GSEQ)
Reagents	GeneChip® Resequencing Reagent Kit

References

1.) High-throughput variation detection and genotyping using microarrays.
D.J. Cutler, et al. Genome Res 11(11): 1913-25 (2001).

2.) New developments in high throughput resequencing and variation detection using high-density microarrays.
J.A. Warrington, et al. Hum Mutat 19: 402-9 (2002).

3.) The Human MitoChip: a high-throughput sequencing microarray for mitochondrial mutation detection
A. Maitra, et al. Genome Research 14(5): 812-9 (2004).

4.) Genomic Alterations in Cultured Human Embryonic Stem Cells
A. Maitra, et al. Nature Genetics Epub (2005 Sep 4).