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About Affymetrix

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Axiom® Human Genotyping Solution

For discovery of human disease genes, drug response biomarkers, or for population genetics, Axiom® Genotyping Solution offers a uniquely flexible choice of innovative, pre-designed arrays covering more populations than any other technology. Arrays have optimized designs enabling combined GWAS, replication, and fine mapping on one study. Axiom Genotyping Solution pre-designed arrays deliver cost-efficient discovery power with the most recent SNP content.

Axiom® myDesign™ Arrays and the Affymetrix design team give you the power to develop the most effective array for your study of human diseases, drug response or populations. Use variants you provide or choose SNPs from our Axiom® Genomic Database, the world's largest resource of genotype-tested SNPs. From whole-genome to targeted variant studies, Axiom myDesign Arrays enable rapid advances in human genetics and high-impact publications.

 

Create your Axiom myDesign Array

Axiom Genotyping Solution includes pre-designed and customized array plates with validated genomic content from the Axiom Genomic Database as well as complete reagent kits, data analysis tools, and a fully automated workflow utilizing GeneTitan® Multi-Channel (MC) Instrument.

Axiom Genotyping Solution includes:

Axiom® Biobank Arrays

Designed by and for thought leaders in the human genetics community for high-throughput, high-value genotyping of large sample cohorts to explore the genetics of complex diseases with a single comprehensive low-cost solution.

Axiom® World Arrays

  • Designed for genome-wide imputation analysis with a focus in disease-associated genes. The arrays include additional markers that are specific to multiple HapMap populations. The use of imputation enables a highly cost-effective, budget conscious alternative to other commercially available arrays.

Axiom® miRNA Target Site Genotyping Arrays

  • The only commercially available high-density microRNA target site genotyping solution. Includes known and predicted SNPs and indels within promoters, miRNA seed sites, precursor miRNA stem-loop regions, mRNA target binding sites, and miRNA processing proteins. Over 80% of the array content is not found on any other genotyping arrays, making it ideal for supplementing GWAS or gene regulation studies.

Axiom® Exome Genotyping Arrays

  • The most comprehensive panel to screen for putative-functional variants in protein-coding regions of the human genome. When combined with genotype data from genome-wide arrays, this panel of rare non-synonymous coding SNPs, indel mutations, and other key GWAS markers is a powerful tool to identify causal variants in complex diseases.

Axiom® Genome-Wide Population-Optimized Human Arrays

  • Human disease research: A suite of population-optimized human Axiom® Genome-Wide Array Plates, pre-designed to maximize genomic coverage of common and rare SNP and indels in Caucasian, Asian, and West African populations

Axiom® myDesign™ Genotyping Arrays

  • Fully customizable Axiom myDesign Genotyping Arrays with SNPs and indels from the Axiom Genomic Database or your own proprietary markers from sequencing initiatives
    • 96-array layout: genotype up to 650,000 SNPs and indels
    • 384-array layout: genotype up to 50,000 SNPs and indels

Axiom® Genomic Database

  • A proprietary database of biologically and analytically validated genomic markers, including content from HapMap, the 1000 Genomes Project, and the NHGRI GWAS Catalog, that enables easy SNP selection as part of the Axiom myDesign program

Axiom® assay

  • Axiom® 2.0 Reagent Kits*, pre-optimized and validated consumables that enable a universal and automated workflow for parallel processing of 96 reactions per plate
  • A manual or fully automated workflow leveraging the Beckman Biomek® FXP Target Prep Express System and GeneTitan® MC Instrument

Axiom™ Analysis Suite
A complete solution to data analysis for all Axiom® arrays. From sample and plate QC to automated genotype calling and SNP classification, this easy-to-use software performs analysis in a single step and allows you to view QC results, summary tables, and SNP cluster graphs.

Axiom® CNV Summary Tools Software

  • A software package that enables CNV analysis using log2 ratios and B allele frequencies from Axiom® intensity and genotyping data. Allows visualization across the genome with drill-down features. Axiom CNV Summary Tools output is also compatible with BioDiscovery Nexus Copy Number™ Software and PennCNV Software.

Fully automated, hands-free workflow

  • Based on the Biomek® FXP Target Prep Express System and GeneTitan® MC Instrument

*Reagent kits do not include plastic consumables required to run the assay on the Beckman Biomek® FXP Target Prep Express System. For a list of required Beckman consumables, please see the Axiom 2.0 Automated Assay User Guide.

For Research Use Only. Not for use in diagnostic procedures.

Axiom Genotyping Solution provides:

The highest genetic coverage – The Axiom Genomic Database's 9.4 million genotype-tested SNPs offer the industry's best coverage of common and rare variants from the 1000 Genomes Project, HapMap, NHGRI, and more. Each variant has been extensively validated in a large number of biological samples to ensure that it is not due to sequencing error, the minor allele can be reliably detected, and that it performs consistently in the Axiom assay.

Flexible format – Design your marker panel with 1,500 to 2.6 million SNPs and indels using the validated markers from the Axiom Genomic Database or your own target sequences.

Rapid results – Validated markers and workflows eliminate the time needed for experimental design and assay optimization.

High-throughput – Process more than up to 3,000 samples per week with end-to-end automated sample processing.

Automated genotype calling and SNP classification – Analyze up to 5,000 samples and export genotype calls for use in downstream analysis.

Confidence in your data – Pre-optimized reagents and validated workflows combined with empirically validated SNPs to generate the most reliable results.

*Reagent kits do not include plastic consumables required to run the assay on the Beckman Biomek® FXP Target Prep Express System. For a list of required Beckman consumables, please see the Axiom 2.0 Automated Assay User Guide.

For Research Use Only. Not for use in diagnostic procedures.

A streamlined assay

Total genomic DNA (200 ng) is amplified and randomly fragmented into 25 to 125 base pair (bp) fragments. These fragments are purified, re-suspended, and hybridized to Axiom Genome-Wide and myDesign Array Plates. Following hybridization, the bound target is washed under stringent conditions to remove non-specific background to minimize background noise caused by random ligation events. Each polymorphic nucleotide is queried via a multi-color ligation event carried out on the array surface. After ligation, the arrays are stained and imaged on the GeneTitan MC Instrument.

Axiom Genome-Wide Genotyping Assay

*Reagent kits do not include plastic consumables required to run the assay on the Beckman Biomek® FXP Target Prep Express System. For a list of required Beckman consumables, please see the Axiom 2.0 Automated Assay User Guide.

For research use only. Not for use in diagnostic procedures.