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GeneChip® Mouse Gene ST Arrays

The Mouse Gene ST Arrays are the latest products in the family of Affymetrix expression arrays offering whole-transcript coverage.

Part # Description Unit Size Your Price (USD)
Qty
902463
GeneChip® Mouse Gene 2.0 ST Array and GeneChip® WT PLUS Reagent Kit
Sufficient for 30 samples    Please Inquire
902462
GeneChip® Mouse Gene 2.0 ST Array and GeneChip® WT PLUS Reagent Kit
Sufficient for 10 samples    Please Inquire
902465
GeneChip® Mouse Gene 1.0 ST Array and GeneChip® WT PLUS Reagent Kit
Sufficient for 30 samples    Please Inquire
902464
GeneChip® Mouse Gene 1.0 ST Array and GeneChip® WT PLUS Reagent Kit
Sufficient for 10 samples    Please Inquire
902119
GeneChip® Mouse Gene 2.0 ST Array
Contains 30 Arrays    Please Inquire
902118
GeneChip® Mouse Gene 2.0 ST Array
Contains 6 Arrays    Please Inquire
902500
GeneChip® Mouse Gene 2.0 ST Array
Contains 2 Arrays    Please Inquire
901171
GeneChip Mouse Gene 1.0 ST Array
Contains 30 Arrays    Please Inquire
901169
GeneChip Mouse Gene 1.0 ST Array
Contains 6 Arrays    Please Inquire
901168
GeneChip Mouse Gene 1.0 ST Array
Contains 2 Arrays    Please Inquire
     

Comprehensive design

Keeping pace with the research community?s understanding of the transcriptome, Affymetrix has designed whole-transcript arrays that include probes to measure both messenger (mRNA) and long intergenic non-coding RNA transcripts (lincRNA). These whole-transcript array designs provide a complete expression profile of mRNA as well as the intermediary lincRNA transcripts that impact the mRNA expression profile.

Research over the past 20 years has predominantly focused on protein coding messenger RNA transcripts and their role in cellular processes, such as disease and development. Recently researchers have identified more that 2,000 transcripts (>200 bases) in the mouse genome with little or no protein coding potential. Only a small fraction of these non-coding RNAs has functional annotations to date. However, there is ample evidence that differential expression of lincRNAs plays an important role in the genesis and progression of disease and that aberrant expression of these molecules have also been linked to cancer. Recent advancements in transcriptome profiling provided evidence of the association of lincRNAs in diverse range of cellular functions:

  • Regulation of mRNA transcription
  • Regulation of mRNA post-transcriptional modifications
  • Occlusion/recruitment of transcription factor binding
  • Activation and transportation of transcription factors
  • Interaction with accessory proteins
  • Guide protein complexes to locations in the genome

Key benefits

  • Comprehensive coverage provides the best opportunity to discover interesting biology
    • >28,000 coding transcripts
    • >7,000 non-coding (include ~2,000) long intergenic non-coding transcripts
  • Measure alternative splicing events/transcript variants with probes designed to maximize exon coverage
  • Reproducible: Intra-lot correlation coefficient =0.99

Content profile

Since the design of the GeneChip® Mouse Gene 1.0 ST Array, there has a substantial increase in the structural and functional understanding of the mouse genome. This increase in knowledge includes the identification of a large number of long intergenic lincRNA that have been identified by the research community. In order to provide the research community with a tool that can measure the differential expression of this exciting class of RNA transcripts, Affymetrix designed the GeneChip Mouse Gene 2.0 ST Array. To supplement the lincRNA data contained in RefSeq, Affymetrix used sequence and transcript data from lncRNA db (http://lncrnadb.com/).

Transcript coverage of the array1 Mouse Gene 1.0 ST Array Mouse Gene 2.0 ST Array

Total RefSeq transcripts covered

26,166

35,240

NM ? RefSeq coding transcript,
well-established annotation

24,582

26,191

NR ? RefSeq non-coding transcript,
well established annotation

1,229

3,391

XM ? RefSeq coding transcript,
provisional annotation

279

1,946

XR ? RefSeq non- coding transcript, provisional annotation

76

3,712

lncRNA transcripts

8

~2,000

RefSeq (Entrez) gene count

21,041

26,515

1 Transcript coverage and gene count derived from RefSeq download as of February 2012.

Data sources used to design the array Mouse Gene 1.0 ST Array Mouse Gene 2.0 ST Array

RefSeq

36

51

Ensembl

41

65

lncRNA db

-

2011

GenBank®

2006

-

"For Research Use Only. Not for use in diagnostic procedures."

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