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GeneChip Essentials - How Affymetrix GeneChip® DNA Microarrays Work
Making Sticky DNA

After the DNA is chopped up, a chemical called biotin (purple cups) are attached to each strand. These biotin molecules will act as a molecular glue for fluorescent molecules that will later be washed over the array. When researchers eventually shine a laser on the array, the fluorescent molecules will glow, showing where the sample DNA has stuck to the DNA probes on the array.

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