GeneChip Rat ToxFX 1.0 Array

The GeneChip^® Rat ToxFX 1.0 Array consists of a single array containing 2,073 probes sets that represent 55 signatures and 22 pathways of direct toxicological interest.

Part #	Description	Unit Size	Your Price (USD)
900994	GeneChip Rat ToxFX 1.0 Array	contains 2 arrays	Please Inquire
900995	GeneChip Rat ToxFX 1.0 Array	contains 6 arrays	Please Inquire
900996	GeneChip Rat ToxFX 1.0 Array	contains 30 arrays	Please Inquire
900997	GeneChip Rat ToxFX 1.0 Array with Reagents	*Contains 30 Arrays and GeneChip® One-Cycle Target Labeling and Control Reagents sufficient for 30 reactions.	Please Inquire

Product
Description

Technical
Documentation

Required/Related
Products

The GeneChip® Rat ToxFX 1.0 Array consists of a single array containing 2,073 probes sets that represent 55 signatures and 22 pathways of direct toxicological interest. Analysis of the microarray data is fully automated through the ToxFX™ Study Builder software and ToxFX™ Analysis Engine, providing exhaustive documentation of the toxicological and pharmacological profile of the drug candidate or compound of interest in an easy-to-read report. ToxFx 1.0 comes with a ToxFX Certificate of Analysis that allows you to generate a full toxicology report.

For more information, please visit www.toxfx.com.

*The GeneChip® Hybridization, Wash and Stain Kit is not included and must be purchased separately.

Rat ToxFX 1.0 Array

Figure 3, Table 1

The Rat ToxFX 1.0 Array comprises a focused subset of content present on the whole-genome Rat Genome 230 2.0 Array; the subset of probes represent genes associated with Drug Signatures® and pathways present in Entelos' DrugMatrix® library (previously Iconix Biosciences).

All probe sets on the Rat ToxFX 1.0 Array are identical to their counterparts on the Rat Genome 230 2.0 Array; the focused array also includes the same hybridization, sample labeling and housekeeping controls. For a full comparison of features, please refer to the Rat ToxFX 1.0 datasheet or view, Figure 3 and Table 1.

Eleven pairs of oligonucleotide probes are used to measure the level of transcription of each gene sequence interrogated by the Rat ToxFX 1.0 Array. The oligonucleotide probes are synthesized in situ using Affymetrix' photolithograthic process, in an identical manufacturing process as the GeneChip® Rat Genome 230 2.0 Array.

ToxFX™ Report

The ToxFX Report is automatically generated as a PDF document and provides an in-depth summary of all aspects of the toxicology study and its results. Data are summarized at a variety of levels, from executive summary to in depth pathway analysis. For more information, please visit www.toxfx.com.

To request a sample ToxFX report, please contact us.

Sections of the report include:

Executive Summary — Single-page summary highlighting key safety issues
Study Description — Detailed record of study design
Drug Signatures — Report on potential safety liabilities based on toxicological matches correlating with more than 50 biological endpoints (e.g., cholestasis, hepatic duct hyperplasia)
Pathways — Detailed analysis and diagrams indicating treatment impact on 22 molecular pathways of key toxicological interest (e.g., bile acid and cholesterol metabolism or oxidative stress)
Toxicologically Relevant Gene Groupings — A single table comprising expression data from noteworthy genes of toxicological interest (e.g., cytochrome P450)
Methodology and Glossary — Documentation of the analytical approaches and terms required to interpret results

For research use only. Not for use in diagnostic procedures.