Scientific Publications
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Affymetrix Microarrays
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DMET Plus Premier Pack The DMET Plus Premier Pack, which includes arrays, reagents, and analysis software, is the most comprehensive, cost-effective product containing known pharmacogenetic markers for drug metabolism studies. |
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Axiom Genotyping Solution The Axiom Genotyping Solution now includes CEU- and ASI-optimized array plates for genome-wide association studies (GWAS), replication studies, and candidate gene association studies. |
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GeneChip® HT Array Plate GeneChip® Array Plates enable researchers to interrogate as many as 96 samples at a time for large-scale expression and genotyping studies. |
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GeneChip® Microarray Affymetrix GeneChip® Microarray |
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GeneChip® Microarray Affymetrix GeneChip® microrray in hand. |
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Array Strips for the GeneAtlas System Affymetrix® Array Strips enable researchers to interrogate four samples at a time on the GeneAtlas System. |
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Array Strips and Hybridization Assembly The novel design of Affymetrix® Array Strips reduces the workflow to basic lab techniques and eliminates the expertise required for other microarray technologies. |
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Affymetrix® Genome-Wide Human SNP Array 6.0 The Affymetrix® Genome-Wide Human SNP Array 6.0 features 1.8 million genetic markers, including more than 906,600 single nucleotide polymorphisms (SNPs) and more than 946,000 probes for the detection of copy number variation. |
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GeneChip® Gene 1.0 ST Array GeneChip® Gene 1.0 ST Arrays focus on well-annotated content to provide a more complete and accurate view of total transcription activity at each genomic locus than classical 3'-based microarrays. |
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GeneChip® Exon 1.0 ST Array The GeneChip Exon Array is the most powerful whole-genome expression tool available today, with more than 5.5 million features on each array and the greatest single-array coverage of the transcriptome. |
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GeneChip® Mapping 500K Array Set The GeneChip® Mapping 500K Array Set enables highly powered whole-genome association studies. It is comprised of two arrays, each capable of genotyping on average 250,000 SNPs. |
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Human Genome U133 Plus 2.0 Array Human Genome U133 Plus 2.0 Array |
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bioMérieux FoodExpert-ID Array bioMérieux FoodExpert-ID Array |
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Xenopus laevis Genome Array Xenopus laevis Genome Array |
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Zebrafish Genome Array Zebrafish Genome Array |
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Affymetrix Instruments
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GeneAtlas System The GeneAtlas System is a complete personal solution for processing Affymetrix microarrays. |
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Affymetrix GeneChip® Scanner 3000 Affymetrix GeneChip® Scanner 3000. |
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Affymetrix GeneChip® Scanner 3000 with workstation Affymetrix GeneChip® Scanner 3000 with workstation. |
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GeneTitan® Instrument The GeneTitan Instrument and the GeneTitan® Multi-Channel (MC) Instrument automate array processing from target hybridization to data generation by combining a hybridization oven, fluidics processing, and state-of-the art imaging device into a single bench-top instrument. |
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Affymetrix History
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First Microarray Prototype Circa 1989: The world's first microarray prototype built by Stephen P.A. Fodor, Ph.D. and colleagues using a microscope slide. |
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Microarray Fabrication Cell Circa 1989: Microarray fabrication cell |
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Photocamera Circa 1989: Photocamera used for early photomask experiments |
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High Contrast film-based Photomask Circa 1989: High contrast film-based photomask |
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500 Micron Manufacturing Mask Circa 1989: High contrast mask made of chrome on glass at a feature size of 500 microns |
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First Microarray Scanner Circa 1989: World's first microarray scanner built by Stephen P.A. Fodor, Ph.D. and colleagues |
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First Microarray Scientific Publication Circa 1991: First scientific publication describing both microarray technology and combinatorial chemistry |
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First Microarray Containing over 1 Million DNA Sequences Circa 1993: World's first microarray containing over 1 million DNA seqences |
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16-Format Manufacturing Mask Circa 1993: 16-format, wafer-based manufacturing mask |
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First Commercial DNA Microarray Prototype Circa 1994: Commercial DNA microarray prototype |
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First Commercial Scanner Circa 1994: World's first commercial microarray scanner manufactured by Molecular Dynamics for Affymetrix |
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49-Format Manufacturing Mask Circa 1995: 49-format, wafer-based manufacturing mask |
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Affymetrix Microarray Scanner by Hewlett-Packard Circa 1997: Microarray scanner manufactured for Affymetrix by Hewlett-Packard |
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400-Format Manufacturing Mask Circa 1999: 400-format, wafer-based manufacturing mask |
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GeneChip® Human Genome U133A array Circa 2002: GeneChip® Human Genome U133A array. Part of a two-array set analyzing over 33,000 genes from the public databases. |
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Affymetrix GeneChip® Scanner 3000 Circa 2003: Affymetrix GeneChip® Scanner 3000 |
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Affymetrix Manufacturing
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| Substrate Cleaning Affymetrix production operator transfers wafers at the cleaning wetbench. |
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| Anti-Reflective Coating Application An anti-reflective coating is applied to the substrate. |
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| Substrate Silanation Bath Affymetrix production operator transfers coated wafers at the silanation wetbench. |
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| Coated Substrate Cassette Affymetrix production operator inspects a cassette of coated substrates. |
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| Chemistry Stations Affymetrix production operator loads a wafer into the modular oligo synthesizer, which performs sequential addition of phosphor ammodites to the wafer. |
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| Nucleotide Addition A wafer is loaded onto the chemical station for nucleotide addition. |
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| Wafer Transfer An Affymetrix operator transfers wafer from the photoaligner to the chemistry station during the photolithographic manufacturing process. |
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| Photolithographic Mask An Affymetrix operator inspects a photolithographic mask prior to installation in the aligner. |
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| Alignment Affymetrix production operator aligns a GeneChip® wafer on the pick-and-place machine, which takes the individual arrays from the wafer and places them into an aluminum tray in preparation for assembly into the GeneChip® cartridge. |
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| Wafer to be Mounted for Dicing A synthesized wafer about to be placed onto the tape mounting station. |
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| Wafer Tape Mount Affymetrix production operator secures the wafer to a tape ring prior to dicing. |
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| Mounted Wafer Inspection Affymetrix production operator inspects a mounted wafer. |
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| Wafer Load for Dicing A mounted wafer is loaded into the dicing saw. |
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| Dicing An Affymetrix wafer being cut into individual arrays by a diamond-bladed saw. One 5x5 array can be cut into as many as 6,400 separate arrays. |
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| Mounted Wafer The wafer after it has been mounted on the adhesive plastic film. |
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| Pick and Place Affymetrix operator glues an array into a plastic GeneChip® cartridge. |
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| Cartridge Labeling Affymetrix production operator inspects a labeled cartridge. |
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| Labeled Cartridge Affymetrix production operator inspects a labeled cartridge. |
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| Bar Code Label A barcoded Affymetrix label is applied to an array. |
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| Hybridization Oven Affymetrix QC technician loads GeneChip® cartridges into the hybridization oven for overnight incubation. The oven's 45C temperature and the rotisserie motion encourage the DNA sample to hybridize to the DNA probes on the array surface. |
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| QC Sample Loading Affymetrix QC technician injects a sample into a cartridge for testing. |
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| Array Scan An Affymetrix QC technician analyzes a scanned image of an array. |
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Affymetrix Personnel
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Kevin King Affymetrix President and CEO |
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Timothy C. Barabe Chief Financial Officer and Executive Vice President |
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Stephen P.A. Fodor, Ph.D. Executive Chairman |
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Stephen P.A. Fodor, Ph.D. Stepehen P.A. Fodor holding a GeneChip® Microarray |
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Robert Lipshutz, Ph.D. Senior Vice President, Corporate Development and Emerging Markets |
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Rick Runkel Executive Vice President, General Counsel and Secretary |
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Affymetrix Technology
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GeneChip® Technology Data from an experiment showing the expression of thousands of genes on a single GeneChip® probe array. Image courtesy of Affymetrix. |
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GeneChip® Array Output Data from an experiment showing the expression of thousands of genes on a single GeneChip® probe array. Image courtesy of Affymetrix. |
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Eukaryotic Target Labeling An overview of eukaryotic target labeling for GeneChip® expression arrays. Image courtesy of Affymetrix. |
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GeneChip® Photolithography GeneChip® probe arrays are manufactured through a unique and robust process, a combination of photolithography and combinational chemistry. Image courtesy of Affymetrix. |
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GeneChip® Single Feature Cartoon depicting a single feature on an Affymetrix GeneChip® microarray. Image courtesy of Affymetrix. |
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GeneChip® Hybridization Cartoon depicting hybridization of tagged probes to Affymetrix GeneChip® microarray. Image courtesy of Affymetrix. |
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Hybridized GeneChip® Microarray Cartoon depicting scanning of tagged and un-tagged probes on an Affymetrix GeneChip® microarray. Image courtesy of Affymetrix. |
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